As most variants identified by GWAS lie outside of protein-coding regions , it is likely that many of these SNPs may reside in as yet-unidentified regulatory elements where transcription factors and chromatin modifiers interact. Addressing these questions will provide a better understanding of the mechanisms underlying cardiovascular disease pathogenesis that will allow the development of better diagnostic tools and therapeutics to address this global health burden.
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Heart disease and stroke statistics — update. A report from the American Heart Association.
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Overview: Gene regulation in bacteria
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